Dr Tess Lawrie writes to Professor Chris Butler requesting the interim results of the trial which as been paused due to ‘supply issues’
Dear Professor Butler
PRINCIPLE: request for interim data on “paused” ivermectin arm
PRINCIPLE is “currently paused due to temporary supply issues”.
We are updating our Systematic Review and Meta-Analysis of ivermectin in Covid-19
(Am. J. Therap. 28, e434-e460) and should like to request your interim results as at the
“pause” point, ideally via de-identified Individual Participant Data (IPD).
You may be aware of recent critiques of meta-analyses based on summary data only
(e.g. Lawrence et al. Nat. Med. 27(11), 1853). There is growing advocacy elsewhere for
access to de-identified IPD for all clinical trials.
Although meta-analyses based on IPD are considerably more laborious than those based
on summary data, it is clear that new standards are being called for.
As a large and visible clinical trial of ivermectin, we should like to request interim results
for the ivermectin and control arms and de-identified IPD for inclusion in our updated
Please let us know your terms and data protection requirements for release of your deidentified
Theresa A Lawrie MB BCh PhD
EbMCsquared, Northgate House, Upper Borough Walls, Bath BA1 1RG
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